Anti-retroviral reverse transcriptase inhibitor.
|Each tablet contains: Lamivudine - 150 mg.|
Treatment of human immunodeficiency virus (HIV) infection in combination with other antiretroviral drugs.
Headache, malaise, nausea/vomiting, diarrhea, anorexia, abdominal cramps, dyspepsia, cough, rhinorrhea, peripheral neuropathy, dizziness, insomnia, depression, arthralgia, myalgia, alopecia, neutropenia, anemia, thrombocytopenia, pancreatitis (in pediatric patients), skin rashes, lipodystrophy syndrome, gynecomastia.
Lactic acidosis and severe hepatomegaly with steatosis have been reported; In non-HIV-infected patients treated with lamivudine for chronic hepatitis B, evidence of exacerbations of hepatitis has occurred after discontinuation of lamivudine; The liver function in these patients should be followed-up for at least 4months. Patients dually infected with HBV and HIV should not be treated in an appropriate combination regimen.
Pregnancy: Category C;
Lactation: Lamivudine treated mothers should be instructed to discontinue breast-feeding;
Elderly: Monitor renal function.
Co-administration of sulfamethoxazole-trimethoprim increases AUC of lamivudine by 44%. Zalcitabine and lamivudine may inhibit the intracellular phosphorylation of one another. Therefore lamivudine is not recommended with Zalcitabine.
Hypersensitivity to any of the components of the formulation.
Administer with or without food.
Adults and adolescents (12 to 16 years): Lavir 150 mg per bid
Paediatrics (3 months to 12 years): Lavir 4 mg/kg bid, maximum 150 mg bid
CrCl =50min/mL=150 mg twice daily, CrCl 30-49 min/mL=150 mg once daily, CrCl 15-29 min/mL=150 mg first dose, then 100mg once daily, CrCl 5-14 min/mL=150 mg first dose then 50mg once daily.
100mg once daily. For patients co-infected with HBV and HIV, a higher dose is indicated as a part of an appropriate treatment regimen. Renal impairment: CrCl =50min/mL=100 mg once daily, CrCl 30-49 min/mL=100 mg first dose, then 50mg once daily, CrCl 15-29 min/mL=100 mg first dose, then 25mg once daily.
Store in a cool, dark and dry place.